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Fukuoka Prefectural University

Education Tagawa, Japan
About:Fukuoka Prefectural University is a education organization based out in Tagawa, Japan. It is known for research contribution in the topics: Anomalous diffusion & Quality of life. The organization has 59 authors who have published 139 publications receiving 2350 citations.


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01 Jul2009 - Diabetes
TL;DR:The strength of association was more prominent in the Japanese population than in Europeans for more than half of the confirmed type 2 diabetes loci and significant associations were replicated in five other candidate loci.
Abstract:OBJECTIVE To identify novel type 2 diabetes gene variants and confirm previously identified ones, a three-staged genome-wide association study was performed in the Japanese population. RESEARCH DESIGN AND METHODS In the stage 1 scan, we genotyped 519 case and 503 control subjects with 482,625 single nucleotide polymorphism (SNP) markers; in the stage 2 panel comprising 1,110 case subjects and 1,014 control subjects, we assessed 1,456 SNPs ( P P –5 for genome-wide exploration and P RESULTS Four loci—1 novel with suggestive evidence ( PEPD on 19q13, P = 1.4 × 10 –5 ) and three previously reported—were identified; the association of CDKAL1 , CDKN2A / CDKN2B, and KCNQ1 were confirmed ( P –19 ). Moreover, significant associations were replicated in five other candidate loci: TCF7L2 , IGF2BP2 , SLC30A8 , HHEX , and KCNJ11 . There was substantial overlap of type 2 diabetes susceptibility genes between the two populations, whereas effect size and explained variance tended to be higher in the Japanese population. CONCLUSIONS The strength of association was more prominent in the Japanese population than in Europeans for more than half of the confirmed type 2 diabetes loci.

237citations

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TL;DR:The study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations, and these variants were in strong linkage disequilibrium.
Abstract:有人建议,奈尔的“节俭genotype” model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations.

137citations

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TL;DR:所谓变量被调查而主题s performed a guilty knowledge test and a dual modality attention task and it was suggested that eye blinks could be related to the selective attention and that eyeblinks could provide an additional index for the detection of deception.
Abstract:所谓变量被调查而主题s performed a guilty knowledge test (Experiment 1) and a dual modality attention task (Experiment 2). In both experiments, the temporal distribution of blinks was analyzed using an automatic video based blink analysis system [Matsuo and Fukuda, Jpn. J. Physiol. Psychol. Psychophysiol., 14 (1996), 17]. In experiment 1, the blink rate pattern discriminated between relevant and irrelevant stimuli. In experiment 2, the blink rate peak after the auditory stimulus disappeared during visually attended tasks whereas the blink rate peak after the visual stimulus was significant during auditory attended tasks. It was suggested that eye blinks could be related to the selective attention and that eye blinks could provide an additional index for the detection of deception.

123citations

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TL;DR:A working memory deficit in OCD is demonstrated by comparison with normal controls and neuropsychological dysfunction and brain abnormalities in OCD are found, which suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychology dysfunction and related brain activities.
Abstract:Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, we applied neuropsychological batteries to demonstrate a working memory deficit in OCD by comparison with normal controls. In addition, working memory and brain activation were further examined with symptom-based analysis. Forty patients with OCD and 25 normal controls were examined using neuropsychological tests including the WAIS-R, WCST, WMS-R, and R-OCFT and functional MRI (fMRI) during the N-back task including 0- and 2-back task. On fMRI, the brain regions activated during the performance and the differences in the activation between patients and controls were identified. Additional analyses of severity and subtypes were conducted by using Y-BOCS severity score, symptom-checklist and Leckman's four-factor model, respectively. On the neuropsychological tests, the OCD patients had significantly lower scores on the delayed recall section of the WMS-R and the immediate recall section of the R-OCFT compared to the controls. On fMRI, the patients showed greater activation in the right dorsolateral prefrontal cortex (DLPFC), left superior temporal gyrus (STG), left insula, and cuneus during two-back task compared to the controls. Right orbitofrontal cortex activity showed a significant positive correlation with Y-BOCS scores in OCD. Furthermore, patients with obsessions/checking rituals (n=10) showed severer memory deficits and decreased activity in the postcentral gyrus than patients with cleanliness/washing rituals (n=14). In conclusion, we found neuropsychological dysfunction and brain abnormalities in OCD. Furthermore, our results suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities.

120citations

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TL;DR:The results suggest that the increase in blinking associated with saccades as a function of time on task, and the pupillary dilation following a blink are associated with aspects of information processing.
Abstract:Introduction: Blinks, saccades, and pupil diameter changes are studied for their application as tools to unobtrusively monitor aspects of performance. Methods: Subjects performed a running memory task for a 60-min period.To evaluate changes in the relationship of blinks to saccades as a function of time on task, the ratio of blinks occurring with and without saccade was calculated for the second following stimulus termination plus the last 0.2 s of stimulus presentation, and also the second preceding stimulus onset plus the initial 0.2 s of stimulus presentation. Changes in pupil diameter following blinks with and without saccades were measured at the beginning, middle, and late in the experiment. Results: Blink frequency increased during both periods as a function of time on task (p < 0.0001). The ratio of blinks concurrent with saccades during the post-stimulus period increased as a function of time on task (p < 0.0001). Pupil diameter increased following blink termination (p < 0.05), regardless of time on task, blink duration, or the presence of a saccade during the blink. Conclusion: Our results suggest that the increase in hlinking associated with saccades as a function of time on task, and the pupillary dilation following a blink are associated with aspects of information processing. These results provide a framework for future studies assessing higher-order cognitive function in operational environments based on measurements of blink, pupil, and saccades.

91citations